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An artificial transcription factor is an example of a chimeral protein, designed to target and modulate gene transcription. They are generally composed of a DNA-binding domain (specific to a certain sequence) coupled to a modulatory domain (which acts upon other transcription factors) in order to alter the expression of a particular gene. It is also possible to downregulate expression of a gene by targeting the 5' untranslated region with a DNA-binding domain that lacks a regulatory domain; this will reduce transcription simply by blocking RNA polymerase progression along the DNA template. == See also == *Therapeutic gene modulation *Zinc finger *Zinc finger protein transcription factor *Chimera (protein) *Protein engineering 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Artificial transcription factor」の詳細全文を読む スポンサード リンク
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